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KMID : 0900219990060010025
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대한비과학회지
1999 Volume.6 No. 1 p.25 ~ p.26
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Allergy-Associated Immune Cell Receptors
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Lee Choong-Eun
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Abstract
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In immune diseases associated with hypersensitivities study. Degranulation of IL-4 production have been implicated by one earlier studies. We recently have been interested in analyzing the abnormal expression of molecules involved in the IL-4 signal transduction system in the immune disease. Results on the IL-4 degranulation in the allergic disease using IL-4 bioassay, Northern blot and RT-PCR technique are presented and the integration of such findings into our present understanding of IL-4/IgE network is discussed. Together our data collectively and strongly suggest that IL-4R and FcεRII exhibit a highly coordinated regulation, both utilize common signal transduction mechanisms by IL-4, anti-CD40, or IFN-γ, and finally both receptors are up-regulated and may thus be involved in IgE-mediate immune disease.
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KEYWORD
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